Pdf cyclophosphamideinduced nephrotoxicity, genotoxicity. Lowdose cyclophosphamideinduced acute hepatotoxicity. Till date, pathophysiology of cyclophosphamideinduced cardiotoxicity is not clearly understood. Ameliorative effect of propolis against cyclophosphamideinduced. Caution should be exercised when handling and preparing cyclophosphamide for injection, usp lyophilized powder, or bottles containing cyclophosphamide tablets. Jan 29, 2012 cyclophosphamide cpm, an alkylating agent is used as an immunosuppressant in rheumatoid arthritis and in the treatment of several cancers as well. Wfb inhibited the dna lesion formation and both wfb and eeb decreased significantly p mechanism affecting the use of cyclophosphamide. Incorporation of metabolic activation potentiates cyclophosphamide. Jul 14, 2014 cardiac toxicity is one of the lifethreatening complications of cancer therapy. Protective eff ects of salvia offi cinalis extract against cyclophosphamide induced genotoxicity and oxidative stress in rats 648 extract was transferred to centrifuge tubes, centrifuged for 10 min 5000 rpm, and subsequently fi ltered through a fi lter paper into a 100ml fl ask. Preclinical perspective of cyclophosphamide induced cardiotoxicity 4. Review on genotoxicity, its molecular mechanisms and prevention. Giesy,4,5,6 zhiming kong,1 yibin cui1 1state key laboratory of pollution control and resource reuse, school of the environment, nanjing university, nanjing 210093, peoples republic of china.
Cardiotoxic side effect of cyclophosphamide is a major challenge. Cyclophosphamide cp, a chemotherapeutic agent, is restricted due to its side effects, especially hepatotoxicity. Till date, pathophysiology of cyclophosphamide induced cardiotoxicity is not clearly understood. The mechanism may involve direct injury to the endothelium by phosphoramide mustard, an active metabolite of cyclophosphamide. If cyclophosphamide is used during pregnancy, or if the. Cyclophosphamide therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of acute liver injury. Protective action against chemicalinduced brazilian. Prophylactic efficacy of melatonin on cyclophosphamide. Antigenotoxicity activity of papaya carica papaya l. Incidence of cyclophosphamideinduced urotoxicity and. Cyclophosphamide is extensively metabolized by the hepatic cytochrome p450 system.
Omega3 fatty acids modulate cyclophosphamide induced markers. After the mice were sacrificed on day 30 liver and colons were removed, the histopathological. Cyc, is a cytotoxic bifunctional alkylating agent, belongs to the class of nitrogen mustards dollery, 1999, tripathi and jena, 2008. Cyclophosphamide cp is a frequently used drug for its anticancer and immunosuppressive potential. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards.
Protective effect of selenium nanoparticle against. Although the precise mechanism of cpinduced testicular toxicity is still not clearly understood, oxidative. Cyclophosphamide fda prescribing information, side effects. Quercetin is known has dna protecting effect antigenotoxic. Preclinical perspective of cyclophosphamideinduced cardiotoxicity 4. Cct fruits extract against cyclophosphamide cpinduced dna damage in mice bone marrow cells was evaluated using micronucleus assay, as an index of induced chromosomal damage. The current study aimed to evaluate the protective effects of melatonin, a pineal secretory product, against hepatotoxicity induced by cyclophosphamide cp in mice. Due to its toxicity, it is replaced as soon as possible by less toxic drugs. Molecular mechanism involved in cyclophosphamideinduced.
Follow the directions on your prescription label carefully, and ask your. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have. Request pdf protective effect of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats the aim of the present study was to evaluate the possible protective effect of. We have to inject cyclophosphamide 100mgkg, 24 hours before. Prevention of cyclophosphamideinduced micronucleus. Cyclophosphamide comes as a tablet to take by mouth once a day. In the genotoxicity evaluation, mice received the extract 500, 1,000, or 2,000 mgkg orally while negative and positive controls were treated with saline solution 0. Cyclophosphamide, liposomeencapsulated, genotoxicity, sister. Because cp is a wellknown genotoxic agent that induces mn formation in mammalian cells 21. We report a case of cyclophosphamide induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. Novel insights into the mechanism of cyclophosphamide. Protective effects of boron on cyclophosphamide induced. Genotoxicity assessment of saline extract from pilosocereus.
Cyclophosphamide n,nbis2chloroethyltetrahydro2h1,3,2oxazaphosphorin2amine 2oxide. Medicinal plants are the food supplements which have not only. In vivo genotoxicity evaluation of crude extract from. Pathogens free fulltext protective effects of evening. Cyclophosphamide is used to treat cancers and autoimmune diseases. However, upon treatment, it induces severe toxicity due to its oxidative stress capabili. Cadmiuminduced genotoxicity, cytotoxicity and lipid. Cyclophosphamideinduced nephrotoxicity, genotoxicity, and damage in kidney genomic dna of swiss albino mice. Here, we applied the metabolic activation system to a ddr and micronucleus mn assays in dt40 cells. Gadjeva3 1department of molecular biology, immunology and medical genetics, faculty of medicine, trakia university, stara zagora, bulgaria. Novel insights into the mechanism of cyclophosphamideinduced. Ginseng alleviates cyclophosphamideinduced hepatotoxicity. Data of 1018 patients 725 women293 men treated with cyc were evaluated in this retrospective study.
Research article prophylactic efficacy of melatonin on cyclophosphamide induced liver toxicity in mice mohammadshokrzadeh, 1,2 amirhosseinahmadi, 1 farshadnaghshvar, 3 aroonachabra, 4 andmehdijafarinejhad 3 pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, kilometers of farah abad road. Evening primrose oil epo contains several phytoconstituents with potent antioxidant and antiinflammatory activities. Cyclophosphamideinduced nephrotoxicity, genotoxicity, and. Handle and dispose of cyclophosphamide in a manner consistent with other cytotoxic drugs. Invitro evidence for cyclophosphamide induced cardiotoxicity. Protective effect of diallyl disulfide on cyclophosphamide. Evaluation of cyclophosphamideinduced genotoxicity and cytotoxicity in. In the present study, we evaluated the potential of the plant e.
Cyclophosphamide cp is an alkylating agent widely used in cancer chemotherapy. Prevention of cyclophosphamideinduced micronucleus formation in mouse bone marrow by solanum lycopersicum extract. Amelioration of the cyclophosphamide induced genotoxic. Cardiac toxicity is one of the lifethreatening complications of cancer therapy.
Research article prophylactic efficacy of melatonin on cyclophosphamideinduced liver toxicity in mice mohammadshokrzadeh, 1,2 amirhosseinahmadi, 1 farshadnaghshvar, 3 aroonachabra, 4 andmehdijafarinejhad 3 pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences. Amelioration of the cyclophosphamide induced genotoxic damage. Cyclophosphamide cp is a wellknown antineoplastic agent. Cyclophosphamide cp is associated with significant pulmonary toxicity. This probably induces sinusoidal obstruction syndrome, leading to a direct toxic effect on sinusoidal cells in the liver, thereby causing necrosis, obstruction, and obliteration of. Cct fruits extract against cyclophosphamide cp induced dna damage in mice bone marrow cells was evaluated using micronucleus assay, as an index of induced chromosomal damage. In vivo genotoxicity evaluation of crude extract from ledum.
A 66yearold caucasian woman with a mediastinal mass diagnosed with. Protective effect of boron on cyclophosphamide induced. In addition, when given in high doses as a part of a myeloablative. The exact mechanism of protection is however tumour 17. However metabolism of cp in the body results into toxic chemical compounds to the liver itself and other nontarget vital organs via oxidative stress, apoptosis induction and finally necrosis. Cyc is widely used at high dose for chemotherapy of various forms of cancer bronchial, breast and ovarian cancer, lymphomas, leukemias, etc. Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug induced bladder complications and screen for bone marrow toxicity. A 66yearold caucasian woman with a mediastinal mass diagnosed with burkitt. An in vitro endothelial model of injury was developed to assess the direct toxic effects of cp, cp derivatives and cp metabolites on cultured endothelial cells. The protective effect of ellagic acid january 2012 molecular and cellular biochemistry. The present study was undertaken to evaluate the natural protective efficacy of methanolic grape seed extract gse against cp induced genotoxicity and histopathologically changes of liver and colon cancer cells in mice.
Omega3 fatty acids modulate cyclophosphamide induced. Therapeutic use of cyclophosphamide and its cytotoxic. Mice were pretreated with melatonin intraperitoneally for 7 consecutive days before the administration of a single intraperitoneal dose of 200 mgkg cp. The objective of the study is to evaluate the protective role of nanose against cpinduced hepatotoxicity and genotoxicity in swiss albino mice. Avocado fruit persea americana mill exhibits chemoprotective potentiality against cyclophosphamide induced genotoxicity in human lymphocyte culture. Research article prophylactic efficacy of melatonin on. The parent compound is inactive in vivo and in vitro and exerts its biological activities through metabolites, mainly phosphoramide mustard, by hepatic microsomal enzymes. Protective effects of salvia officinalis extract against. Cyclophosphamide cpm, an alkylating agent is used as an immunosuppressant in rheumatoid arthritis and in the treatment of several cancers as well.
Since there is no escaping of using such medications in spite of their harms this. The present study was aimed to examine and evaluate the genotoxicity and. Ameliorative effect of peach seed extract on cyclophosphamide. Protective eff ects of salvia offi cinalis extract against cyclophosphamideinduced genotoxicity and oxidative stress in rats 648 extract was transferred to centrifuge tubes, centrifuged for 10 min 5000 rpm, and subsequently fi ltered through a fi lter paper into a 100ml fl ask. Prevention of cyclophosphamideinduced micronucleus formation.
Protective effect of boron on cyclophosphamide induced lipid. Shortterm comparative study of the cyclophosphamide. Genotoxic and histopathological aspects of treatment with. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. The effect of boron b on cyclophosphamide cyc induced damage in liver 1, kidney 2, heart 3, brain 4 and lung 5 of rats.
Therapeutic use of cyclophosphamide and its cytotoxic action. Pdf evaluation of cyclophosphamideinduced genotoxicity and. The present study was undertaken to evaluate the natural protective efficacy of methanolic grape seed extract gse against cpinduced genotoxicity and histopathologically changes of liver and colon cancer cells in mice. Unlike anthracyclines, cyclophosphamideinduced cardiotoxicity does not appear to be cumulative. Medicinal plants are the food supplements which have not only nutritional value but. Research article the mitigating effect of citrullus.
Acute pneumocyte injury, polyadpribose polymerase activity, and pyridine nucleotide levels after in vitro exposure of murine lung slices to cyclophosphamide. The clinical use of cyclophosphamide and ifosfamide is limited by a resultant bladder toxicity which has been attributed to the metabolite acrolein. Ginseng has often been clinically used with cp in china, but whether and how. Tranilast ameliorates cyclophosphamideinduced lung injury. Possible genoprotective effect of citrullus colocynthis l. Dec 04, 2019 cyclophosphamide cp is a frequently used drug for its anticancer and immunosuppressive potential. Sep 04, 20 the mechanism of cyclophosphamideinduced hepatitis is not clearly understood. Another metabolite chloroacetaldehyde caa associated with nephrotoxicity, has not been investigated for toxicity in the bladder and this study investigates the effects of acrolein and caa on human urothelial cells in vitro. Protective effect of salacia oblanga and quercetin on. Protective effects of eicosapentaenoic acid on genotoxicity. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma.
The mechanism of cyclophosphamideinduced hepatitis is not clearly understood. Original contribution modulatory effects of total extract of. The objective of the study is to evaluate the protective role of nanose against cp induced hepatotoxicity and genotoxicity in swiss albino mice. Results from the current study suggested that qe and so supplementation attenuates cp induced genotoxicity through a mechanism related to their ability to decrease oxidative stress and inflammation, in addition, so and qe may play a role in reducing cytogenotoxicity induced by antineoplastic drugs during cancer chemotherapy.
In eucaryotes, it was proposed that the genotoxicity of metals results from nondirect formation of ros 36,37. Cyclophosphamide cpa is an effective chemotherapeutic agent, but has side effect, causing dna damage genotoxic. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. Injury to 51crlabeled bovine artery pulmonary endothelial bpae cells was quantified by the release of 51cr from. Its seem to have a preventive potential against cp induced micronuclei formation in swiss mouse bone marrow cells. Genoprotective and genotoxic effects of thymoquinone bioline.
Herbal medicines remain an important component of the health care system. As an immune suppressor it is used in nephrotic syndrome, granulomatosis with polyangiitis. Mice were preadministered with different doses of cct via intraperitoneal injection for 7 consecutive days followed by injection with. Protective eff ects of salvia offi cinalis extract against. Protective effects of boron on cyclophosphamide induced lipid. In this study, ellagic acid ea, a naturally occurring plant polyphenol, was evaluated for its antigenotoxicity and antioxidant efficacy against the cpminduced renal oxidative stress and genotoxicity in swiss albino mice. In this study, ellagic acid ea, a naturally occurring plant polyphenol, was evaluated for its antigenotoxicity and antioxidant efficacy against the cpm induced renal oxidative stress and genotoxicity in swiss albino mice. Take cyclophosphamide at around the same time every day. Pol j antioxidant enzymes, lipid peroxidation rate and lipid pharmacol, 56. Cyclophosphamide is effective against a wide spectrum of malignancies, such as leukemia, lymphoma, breast, lung, prostate, and ovarian cancers. Invitro evidence for cyclophosphamideinduced cardiotoxicity. With increased success rate of cancer treatment, due in part to the aggressive use of. Cyclophosphamide cp is commonly used chemotherapeutic and immunosuppressive agent for the treatment of a wide range of neoplastic as well as some utoimmune diseases.
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